Novel barbituric acid derivatives, methods for their preparation and pharmaceutical preparations containing these compounds

摘要

The present invention relates to a pharmaceutical formulation containing a compound of formula (I), a pharmacologically acceptable salt thereof and a prodrug thereof and its optically active form, a process for its preparation and a compound having a substrate metalloprotease-inhibiting action:;[Formula I];[Wherein,;X, Y and Z are independently of each other oxygen, sulfur or NH; R ₁ is a group WV (W is a simple bond or one or several optionally substituted straight or branched C ₁ -C ₈ alkyl or C ₂ -C ₈ alkenyl groups, V may contain one or several heteroatoms) Optionally substituted monocyclic or bicyclic, or W-V is a C ₁ -C ₂₀ alkyl group optionally substituted with heteroatoms and optionally substituted by one or several carbon atoms; R ₂ and R ₃ represent hydrogen or one of them represents lower alkyl or lower acyl; R ₄ and R ₅ independently of one another, AD (where A is-, alkyl, alkenyl, acyl, alkylsulfonyl, sulfonyl, alkylaminocarbonyl, aminocarbonyl, alkoxycarbonyl, oxy-carbon Carbonyl, alkylaminothiocarbonyl, one or several optionally substituted aminothio-carbonyl, D represents hydrogen, monocyclic or bicyclic, wherein monocyclic or bicyclic is optionally inserted one or several times between heteroatoms , Monocyclic or bicyclic is substituted one or several times); R ₄ and R ₅ together with the adjacent N atoms form a ring].