Borrelia burgdorferi immunologically active proteins, test kits containing these proteins and suitable for detecting antibodies in test liquids, monoclonal antibodies directed against the immunologically active proteins and the use of these proteins as vaccines against infections caused by Borrelia strains

摘要

Immunologically active proteins (I) of Borrelia burgdorferi, in a form free of other proteins derived from B. burgdorferi, are new. (I) are recombinant proteins with molecular wts. of 17 kD (p17), 22 kD (pC), 41 kD (p41 = flagellin), 100 kD (p100) and 31 kD (OspA). The amino acid sequences of pC, p41, p100 and OspA are given. (I) have been produced by cloning restriction fragments of DNA from B. burgdorferi (DSM 5662) in E. coli.