humanized (b10, an anti il-2 receptor antibodies

摘要

PCT No. PCT/JP92/01583 Sec. 371 Date May 10, 1994 Sec. 102(e) Date May 10, 1994 PCT Filed Dec. 3, 1992 PCT Pub. No. WO93/11238 PCT Pub. Date Jun. 10, 1993A humanized antibody is provided, which is obtained by transplantation of the complementarity determining region of a mouse monoclonal antibody B-B10 specific to a human IL-2 receptor into a human antibody. The antibody has a very low antigenicity, and therefore, it is useful for treatment of carcinoma expressing IL-2 receptor.