首页> 外国专利> Treatment with an anti EGFR Antibody of IgG class and with a Humanized Antibody against receptor for insulin-like growth factor 1

Treatment with an anti EGFR Antibody of IgG class and with a Humanized Antibody against receptor for insulin-like growth factor 1

机译:用IgG类抗EGFR抗体和抗胰岛素样生长因子1受体的人源化抗体治疗

摘要

This application provides an Antibody anti EGFR (epidermal growth factor receptor) and a class of LGG Antibody Humanized igf-1r for Combined use in the treatment of cancer, with or without additional agents or treatments, such as other Anticancer Drugs Or Radiation Therapy.The application also includes a Pharmaceutical composition comprising a combination of an anti EGFR Antibody and IgG Class Antibody Humanized igf-1r in a pharmaceutically acceptable Carrier.Claim 1: anti EGFR Antibody IgG Antibody and Humanized igf-1r for Combined use in the treatment of cancer, in which the anti EGFR Antibody Class TGG comprises: (a) in the heavy chain variable Domain, a sequence id no. 1 SEC CDR1, CDR2 of seq Ncia SEC ID no. 16, and CDR3 Sequence SEC ID no 31, and (b) in the variable domain of light chainA sequence id no. 33 sec CDR1, CDR2 Sequence SEC ID no 34, and CDr3 sequence id no. 35 sec.
机译:本申请提供了一种抗体抗EGFR(表皮生长因子受体)和一类LGG抗体人源化igf-1r,可联合用于癌症的治疗,无论是否需要其他药物或疗法,例如其他抗癌药物或放射疗法。本申请还包括在药物可接受的载体中包含抗EGFR抗体和IgG类抗体人源化igf-1r的组合的药物组合物。权利要求1:抗EGFR抗体IgG抗体和人源化igf-1r的组合用于治疗癌症,其中抗EGFR抗体类别TGG包含:(a)在重链可变域中,序列ID为no。 1 SEC CDR1,SEQ2 Ncia SEC ID编号的CDR2。 16,CDR3序列SEC ID no 31和(b)轻链可变域中的序列id no。 33秒CDR1,CDR2序列SEC ID编号34和CDr3序列ID编号35秒

著录项

  • 公开/公告号AR080188A1

    专利类型

  • 公开/公告日2012-03-21

    原文格式PDF

  • 申请/专利权人 ROCHE GLYCART AG;

    申请/专利号AR2011P100465

  • 发明设计人

    申请日2011-02-16

  • 分类号C07K16/28;C07K14/485;A61K39/00;A61P35/00;

  • 国家 AR

  • 入库时间 2022-08-21 17:25:36

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