Compound, processes for the preparation of seed crystals of the thermodynamically stable modification of ramatroban, for the preparation of a thermodynamically stable form of ramatroban, medicament, and, use of a thermodynamically stable modification of ramatroban

摘要

"COMPOUND, PROCESSES FOR THE PREPARATION OF SEED CRYSTALS OF THE THERMODINAMICALLY STABLE MODIFICATION I OF RAMATROBAN, FOR THE PREPARATION OF A THERMODYNAMICALLY STABLE FORM OF RAMATROBAN, MEDICATION, AND, USE OF A MODIFICATION OF THERMODYNAMENTALLY ABOUT THIS PROVISION. thermodynamically stable modification of the active compound of ramatroban of formula (I) The thermodynamically stable form is prepared by melting the metastable form and subsequent recrystallization or by seeding a solution of the metastable active compound with a seed crystal of the thermodynamically stable form. The thermodynamically stable active compound can be used as an asthma agent.