USE OF SULPHONAMIDE DERIVATIVES FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS POTENTIATING GLUTAMATE RECEPTOR FUNCTION

摘要

The present invention relates to the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for enhancing glutamate receptor function. Compounds of general formula (Ia) represented by the general formula (I) are novel and are also within the scope of the invention. The invention also relates to pharmaceutical compositions containing the compounds of formula (Ia), and also to a process for the preparation of the compounds of formula (Ia), which is a narrower group of compounds of formula (Ia). In the general formulas, the substituents are defined as many, for example, R1 is an optionally substituted aromatic or heteroaromatic group, R2 is C1-6alkyl, C3-6cycloalkyl, C1-6-fluoroalkyl, C1-6 chloro. alkyl, C 2-6 alkenyl, (C 1 -C 4) alkoxy (C 1 -C 4) alkyl, phenyl optionally substituted with halogen, C 1-4 alkyl or C 1-4 alkoxy, or R 3 R 4 N wherein R3 and R4 are independently C1-C4 alkyl or together with the nitrogen atom to which azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydro-azepinyl or octahydroazocinyl are attached; L is C 2 -C 4 alkylene optionally substituted with one or two C 1-6 alkyl, aryl (C 1-6) alkyl, C 2-6 alkenyl, aryl (C 2 -C 6) alkenyl, and aryl. or the C 2-4 alkylene group may have two substituents which, together with the atom or carbon atoms to which they are attached, form a 3-8 carbon atoms carbocyclic ring, R 14 is an optionally substituted phenyl group. The compounds of formula (I) or pharmaceutically acceptable salts thereof may be used for the treatment and prevention of detection disorders, neurodegenerative diseases, dementia of the elderly, memory deterioration, disorders of movement, depression, attention deficit disorders, psychosis-related disorders. HE