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USE OF SULPHONAMIDE DERIVATIVES FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS POTENTIATING GLUTAMATE RECEPTOR FUNCTION
USE OF SULPHONAMIDE DERIVATIVES FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS POTENTIATING GLUTAMATE RECEPTOR FUNCTION
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机译:使用磺酰胺衍生物制备潜在的谷氨酸受体功能的药物组合物
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摘要
Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formula R1-L-NHSO2R2 in which R1 represents an unsubstituted or substituted aromatic or heteroaromatic group; R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C)chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group, of formula R3R4N in which R3 and R4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; and L represents a (2-4C)alkylene chain which is unsubstituted or substituted by one or two substituents selected independently from (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl and aryl, or by two substituents which, together with the carbon atom or carbon atoms to which they are attached form a (3-8C)carbocyclic ring; and pharmaceutically acceptable salts thereof. Also disclosed are novel compounds of formula I, processes for preparing them and pharmaceutical compositions containing them.
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机译:可以使用有效量的式R 1 -L-NHSO 2 R 2化合物增强哺乳动物中的谷氨酸受体功能,其中R 1代表未取代或取代的芳族或杂芳族基团; R 2表示(1-6C)烷基,(3-6C)环烷基,(1-6C)氟烷基,(1-6C)氯烷基,(2-6C)烯基,(1-4C)烷氧基(1-4C) )烷基,未被取代或被卤素取代的苯基,(1-4C)烷基或(1-4C)烷氧基或式R 3 R 4 N的基团,其中R 3和R 3 4>各自独立地表示(1-4C)烷基,或与它们所连接的氮原子一起形成氮杂环丁烷基,吡咯烷基,哌啶基,吗啉代,哌嗪基,六氢pin庚啶基或八氢azo唑基。 L表示未被取代或被一个或两个独立地选自(1-6C)烷基,芳基(1-6C)烷基,(2-6C)烯基,芳基(2-)的取代基取代的(2-4C)亚烷基链。 6C)烯基和芳基,或两个取代基与它们所连接的一个或多个碳原子一起形成(3-8C)碳环;及其药学上可接受的盐。还公开了式I的新型化合物,其制备方法和包含它们的药物组合物。
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