T-PEPTIDE AND ASSOCIATED PEPTIDES INTENDED FOR THE TREATMENT OF INFLAMMATIONS, PARTICULARLY MULTIPLE SCLEROSIS.

摘要

PEPTIDO T AND ITS LINEAR OR CYCLICAL ANALOGS OF THE GENERAL FORMULA (1): I-A-B-C-D-E-F-G-H-II, WHERE A IS ALA, GLY, VAL, SER, THR OR ABSENT, B IS ALA, GLY, VAL, SER, THR OR ABSENT; C IS SER, THR OR ABSENT, D IS SER, THR, ASN, GLU, ARG, ILE, LEU OR ABSENT, E ES SER, THR, ASP OR ABSENT, F ES THR, SER, ASN, ARG, GLN, LYS, TRP O ABSENT, G IS TYR OR ABSENT, H IS THR, ARG, GLY, MET, MET (O), CYS, THR, GLY, O ABSENT EI ES CYS OR ABSENT, II IS CYS, AMIDA GROUP, SUBSTITUTED AMIDA GROUP , AN ESTER OR ABSENT GROUP, AT LEAST ONE OF THE AMINO ACIDS OPTIONALLY REPLACED BY A POLYMERIC OR MONOMERIC CARBOHYDRATE OR DERIVATIVES THEREOF, SUCH SUBSTITUTION IS MADE THROUGH HYDROXYL AND / OR AMIDO AND / OR AMIDES WHICH INCLUDE AT LEAST 4 AMINO ACIDS, AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, ARE USED IN THE TREATMENT OR PREVENTION OF INFLAMMATION. IN PARTICULAR, PEPTIDES ARE USED IN THE TREATMENT OR PREVENTION OF MULTIPLE SCLEROSIS, MYELOPATHIES (INCLUDING MYLOPATHY ASSOCIATED WITH HTLV-1) AND SYMPTOMS AND DISEASES ASSOCIATED WITH CHRONIC IMMUNE ACTIVATION, INCLUDING INTESTINE AND ANPHITRION ANSWERS AGAINST GRAFT AND GRAFT AGAINST HOST IN TRANSPLANT RECEIVERS.