PEPTIDE T AND ASSOCIATED PEPTIDES INTENDED FOR THE TREATMENT OF INFLAMMATION INCLUDING MULTIPLE SCLEROSIS.

摘要

THE INVENTION REFERS TO THE PEPTIDE T AND ITS CYCLING ANALOGS OF GENERAL FORMULA 1: WHERE IS IT ALLA, GLY, VA, SER, THR OR IS ABSENT; B IS ALA, GLY, VAL, BE, THR OR IS ABSENT; C IS BE, THR, OR IS ABSENT; D ES BE, THR, ASN, GLU, ARG, ILE, LEU OR IS ABSENT; E IS BEING, THR, ASP OR IS ABSENT; F ES THR, SER, ASN, ARG, GLN, LYS, TRP OR IS ABSENT; G IS TYR OR IS ABSENT; H ES THR, ARG, GLY, MET, MET (O), CYS, THR, GLY OR IS ABSENT; AND I IS CYS OR IT IS ABSENT; II IS CYS, AN AMIDA GROUP, A REPLACED AMIDA GROUP, AN ESTER GROUP, OR IS ABSENT; AT LEAST ONE OF THE AMINO ACIDS IS OPTIONALLY REPLACED BY A MONOMERIC OR POLYMERIC CARBOHYDRATE OR A DERIVATIVE OF THE SAME, CARRYING OUT THAT SUBSTITUTION THROUGH THE HYDROXYL AND / OR AMINO ACIDS GROUPS. THESE PEPTIDES INCLUDE AT LEAST 4 AMINO ACIDS, AND THE PHARMACEUTICALLY ACCEPTABLE SALTS ARE ALSO INCLUDED. SUCH PEPTIDES ARE USEFUL FOR THE TREATMENT OR PREVENTION OF INFLAMMATION, ESPECIALLY OF MULTIPLE SCLEROSIS, HONEYOPATHY (INCLUDING MYELOPATHY ASSOCIATED WITH HTLV-1) AND SYMPTOMS AND DISEASES ASSOCIATED WITH THE IMMUNE CRITICAL ACTIVATION TOXICO, ARTHRITIS, THE FLAMMABLE COLON SYNDROME AND THE ANSWERS OF GUEST AGAINST GRAFT AND INJERT AGAINST GUESTS, IN TRANSPLANTATION RECEPTORS.