gel for local hormonal therapy of vaginal dryness

摘要

The disclosed gel is intended to a local treatment, essentially non systemic, of the vaginal dryness, particularly in menopaused women. It is characterized by the synergic combination of a natural oestrogen selected amongst 17 beta -estradiol and its salts and a biodegradable, hydrophilic, lubricant and bioadhesive gel. The oestrogen contents is selected so as to obtain a unit dose equivalent to 15 mu g at the most, preferably less than 10 mu g of 17 beta -estradiol, and this special substance is intended to be applied to the vulvo-vaginal mucosa. The oestrogen is present in the gel either in a preferably micronized free form, or in a vectorized form, particularly by encapsulation in vectors of the nanoparticle type such as supramolecular biovectors. The excipient comprises preferably carboxyvinylic acid, glycerin, a pH adjusting substance, a preservation adjuvant and an aqueous excipient.