Compound, pharmaceutical composition, agent to control retinoid-related receptors, diabetes mellitus prevention and therapy processes, hyperlipemia prevention and therapy, to enhance insulin sensitivity, to improve insulin resistance, prevention and therapy of impaired glucose tolerance, prevention and therapy of an inflammatory disease, prevention of arterial sclerosis, and, use of the compound

摘要

"COMPOSITE, PHARMACEUTICAL COMPOSITION, AGENT TO CONTROL RETINOID-RELATED RECEPTORS, DIABETES MELLITUS PREVENTION AND THERAPY PROCESSES, PREVENTION AND THERAPY OF HYPERLIPEMIA, TO ACCOMPLISH A INSULIN SENSITIVITY, IMPROVEMENT, IMPROVEMENT OF INSULIN, IMPROVEMENT FROM TOLERANCE TO HARMED GLUCOSE, PREVENTION AND THERAPY FOR AN INFLAMMATORY DISEASE, PREVENTION AND THERAPY FOR AN ARTERIAL SCLEROSIS, AND, USE OF THE COMPOUND "To provide a new derivative of oxyiminoalkanoic acid that has excellent hypoglycemic and hypolidemic actions to be used for hypoglycemic and hypolipidemic and hypolipidemic and hypolipidemic actions. prevention or treatment of diabetes mellitus, hyperlipemia, insulin insensitivity, insulin resistance and impaired glucose tolerance. A compound represented by formula (a) in which R¹ is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond, -CO-, -CH (OH) - or a group represented by -NR ^ 6 ^ - where R ^ 6 ^ is a hydrogen atom or an optionally substituted alkyl group; n is an integer from 1 to 3; Y is an oxygen atom, a sulfur atom, -SO-, -SO ~ 2 ~ - or a group represented by -NR ^ 7 ^ - where R ^ 7 ^ is a hydrogen atom or an alkyl group optionally; ring A is a benzene ring optionally having one to three additional substituents; p is an integer from 1 to 8; R ~ 2 ~ is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; q is an integer from 0 to 6; m is 0 or 1; R³ is a hydroxy group, OR ^ 8 ^ (R ^ 8 ^ is an optionally substituted hydrocarbon group) or NR ^ 9 ^ R ^ 10 ^ (R ^ 9 ^ and R ^ 10 ^ are the same or different groups that are selected from a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group or R ^ 9 ^ and R ^ 10 ^ combine together to form a ring); R ^ 4 ^ and R ^ 5 ^ are the same groups or different groups that are selected from a hydrogen atom or from an optionally substituted hydrocarbon group in which R ^ 4 ^ can form a ring with R ^ 2 ^; provided that when R¹ is an ethoxymethyl, a C ~ 1-3 ~ alkyl, phenyl or p-methoxyphenyl and q = m = 0, R³ is NR ^ 9 ^ R ^ 10 ^; and as long as O- [2-chloro-4- (2-quinolylmethoxy) phenylmethyl] oxime and a methyl pyruvate of [2-chloro-4- (2-quinolylmethoxy) phenylmethyl-2-iminoxypropionic acid are excluded; or a salt like this.