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ENZYMATIC CLEAVAGE OF FUSION PROTEINS; FUSION PROTEINS; RECOMBINANT DNA AND PHARMACEUTICAL COMPOSITIONS
ENZYMATIC CLEAVAGE OF FUSION PROTEINS; FUSION PROTEINS; RECOMBINANT DNA AND PHARMACEUTICAL COMPOSITIONS
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机译:融合蛋白的酶切;融合蛋白;重组DNA和药物成分
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摘要
For the enzymatic cleavage of fused proteins and obtaining of desired portions of these fused proteins, (1) genetic engineering means are used to modify a junction region in which two portions of the fused protein are connected together so that in this junction region at least one IgA protease recognition site with the amino-acid sequence Y-Pro. &darr& .X-Pro is produced, where X can be any amino acid and Y can be any one or more amino acids, (2) the fused protein resulting from step (1) is cleaved by IgA protease at the position identified by . &darr& . in the recognition site and (3) after the cleavage one or more desired portions of the fused protein are obtained.
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