Reagents and procedures quantification of imipramine or desipramine in biological fluids.

摘要

They ARE PRESENTED immunoassay methods and reagents for quantification of imipramine or desipramine SPECIFIED IN A test sample. MEASUREMENTS imipramine or desipramine PERFORMED IN A SPECIFIC immunoassay employing antibodies raised with derivatives of imipramine or desipramine of formula (III), where p is a carrier material immunogenic, X is two heteroatoms, Y is a linking group comprising 1A to 6 carbon atoms, p is an immunogenic carrier material, and wherein for imipramine R is CH3, Y for desipramine, R is H. The present invention also discloses SYNTHESIS REAGENTS lABELED SOLE STRUCTURE OF FORMULA ( IV), wherein Z is a linking group containing 1 to 4 carbon atoms and 0 to 2 hetero atoms and q is a detectable UNIT, pREFERABLY FLUORESCENT dERIVATIVE fLUORESCENCE AND WHERE TO IMIPRAMINA R1 is CH3 AND desipramine, R1 IT'S H.