Conjugates of hpma copolymer and ellipticin

摘要

Polymer and copolymer conjugates of a bioactive heterocyclic compound, the general structure of which is represented by formula (I). In a preferred embodiment 6-(3-aminopropyl)-ellipticine (APE) is linked to a copolymer via pendent, lysosomally labile peptide side-chains. The bioactive agent is linked to the polymer using aminolysis of carboxyterminal p-nitrophenyl ester groups represented by formula (II) (Ulbrich et al., 1996).