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TNP-470-HPMA-METHACRYLIC ACID COPOLYMER CONJUGATES AND USE THEREOF
TNP-470-HPMA-METHACRYLIC ACID COPOLYMER CONJUGATES AND USE THEREOF
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机译:TNP-470-HPMA-甲基丙烯酸共聚物共轭物及其使用
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摘要
The present invention relates to conjugates of water-soluble polymers and o-(chloracetyl-carbamoyl) fumagillol (TNP-470) and use of those conjugates as specific intracellular carriers of the TNP-470 into tumor vessels. The present invention further relates to use of those conjugates to lower the neurotoxicity of TNP-470. Preferably, the polymer has a molecular weight in the range of 100 Da to 800 kDa. More preferably, the polymer has a molecular weight no greater than 60 kDa. Most preferably, the polymer has a molecular weight in the range of 15 kDa to 40 kDa.
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