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A novel baculovirus/adenovirus hybrid vector for the rescue, production and titration of high-capacity adenovirus amplicon vectors

机译:新型杆状病毒/腺病毒杂交载体,用于抢救,生产和滴定大容量腺病毒扩增子载体

摘要

The present invention describes a recombinant baculovirus hybrid helper virus that is comprised of baculovirus sequences and second viral structural and late viral sequences. The invention also describes a method of producing gutless viral vectors that are substantially free from helper virus contamination. Furthermore, the invention describes a recombinant baculovirus BAC-B4 (VSVG).
机译:本发明描述了重组杆状病毒杂种辅助病毒,其由杆状病毒序列以及第二病毒结构和晚期病毒序列组成。本发明还描述了一种生产基本上不含辅助病毒污染的无肠病毒载体的方法。此外,本发明描述了重组杆状病毒BAC-B4(VSVG)。

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