PEPTIDES INHIBITING VASCULAR ENDOTHELIAL CELL MIGRATION

摘要

The present invention provides novel peptides inhibiting vascular endothelial cell migration, which are useful as an agent for treating diseases relating to pathological angiogenesis, for example, solid tumor, inflammatory diseases such as arthritis, ocular angiogenic diseases such as diabetic retinitis, or the like.;The present invention provides peptides having an activity of inhibiting vascular endothelial cell migration represented by the following formula (I):        R¹-A-R²     (I)wherein R¹ represents a hydrogen atom, substituted or unsubstituted alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroarylcarbonyl, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted aryloxycarbonyl, or substituted or unsubstituted heteroaryloxycarbonyl; R² represents hydroxy, substituted or unsubstituted alkoxy, or substituted or unsubstituted amino; and A represents a partial amino acid sequence of the amino acid sequence represented by any of SEQ ID NOs:1 to 3 wherein one or more amino acid residue may be substituted, deleted or added, or pharmaceutically acceptable salts thereof.