Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands

摘要

Disclosed are compounds encompassed by the following general formula: chemistry chemdraw filechemistry mol file;wherein, ;A represents ethenylene, or A represents XCH₂; where X is carbon or oxygen, provided that when X is oxygen, the oxygen is adjacent the 6-membered ring; ;R₁, R₂, R₃ and R₄ are inorganic or organic substituents; and ;R₅ and R₆ is are optionally substituted organic substituents; or ;NR₅R₆ represents a carbocyclic or heterocyclic six membered ring optionally substituted with various orgainic or inorganic groups, ;which compounds can be used in the treatment of neuropsychological disorders.