(2S) -1-(2R, 3S) -5-chloro-3- (2-chlorophenyl) -1- (3,4-dimethoxybenzenesulfonyl) -3-hydroxy-2,3-dihydro-1H-indole -2-carbonyl pyrrolidine-2-carboxamide

摘要

An improved process for preparing (2S)-1-[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxybenzenesulphonyl)-3-hydroxy-2,3 -dihydro-1H-indole-2-carbonyl]pyrrolidine-2-carboxamide by cyclization of (2S)-1-{[[4-chloro-2-(2-chlorobenzoyl)phenyl]-(3,4-dimethoxybenzenesulphonyl)amino]acetyl}pyrrolidine-2-carboxamide in the presence of an alkali metal hydroxide in a mixture of polyethylene glycol and water.