A polypeptide comprising a muteina interleukin - 2 - Human, a Pharmaceutical composition that comprises a polynucleotide, a prokaryotic cell and eukaryotic Cell, an isolated, a Vector

摘要

A polypeptide containing an yi-2 type human mutualist of Yiye type yi-2 number, in which case, at least one of the 20th, 88th or 126th positions of the yi-2 type human is replaced, so that the active interaction of t-kangnai is better than that of NK cells. In particular, the difference of T cell activity between d20h EI, n88g, I and R is much greater than that of local IL-2, and the prediction of related toxicity is reduced. It also provides the polyvinylchloride otidos, a carrier containing polynucleotide, and a host cell for editing the interaction in the invention,Drug ingredients with inducements and inducements for drug manufacture.