S-OXIDE AND S,S,-DIOXIDE TETRAHYDROTHIOPYRAN PHENYLOXAZOLIDINONES, THEIR USE FOR PREPARATION OF PHARMACEUTICAL COMPOSITIONS AND PROCESS FOR DETERMINING THE INHIBITORY ACTIVITY OF COMPOUNDS TO HUMAN MONOAMINO OXIDASE

摘要

The present invention relates to compounds of general formula (I) and (II) having antimicrobial activity, wherein R1 is methyl, ethyl, cyclopropyl or dichloromethyl, R2 and R3 are independently hydrogen or fluorine and R4 is ethyl or dichloromethyl. . The present invention relates to the use of the above compounds for the preparation of a pharmaceutical composition which can be administered as an antibacterial agent. The compounds of formula (I) and (II) have the advantage of moderately inhibiting the activity of monoamine oxidase (MAO) with known oxazolidinone derivatives, resulting in the absence of various side effects. The present invention also provides a novel assay for determining the inhibitory effect of oxazolidinone derivatives and other compounds on human monoamine oxidase. SHE