Inhibitors of Matrix Metalloproteinases pirimidinonas based merging

摘要

Refers to pirimidinonas biciclicas formula I where W together with the carbon Atoms to which they are united in the Group a, B, among others.A - C -, - S -, B -, NR5, and together form a - B - C = C; X is o, S, so, SO2, NR5, and is o, S, R1, R4 and R5 are h, alkyl alquenilo C1 - C2 - C6 C6 alquinilo C2 - C6, among others; R2 and R3 are h,C1 - C6 alkyl, alquenilo C2 - C6, among others; R2 is Halo; n is 0 - 5; R4 and R5 together to complete a Ring EC 3 to 8 members.Preferred compounds are acid 4 - (6 - [3 - (4 - methoxy phenyl) - 1 - inil prop -] - 1 - methyl - 2 - [- 1,4 - dihydro - 2H thieno [2,3-d] pyrimidin-2-yl) - 3 - Methyl benzoic acid,3 - (4 - metanosulfonil - benzyl) - 6 - [3 - (4 - methoxy phenyl) - 2 - 1 - 1 - methyl - inil] - 1H thieno [2,3-d] pyrimidine - 2.4 - dione, among others. It also relates to a Pharmaceutical composition.These compounds are inhibitors of metalloproteinases and are useful for the treatment of Arthritis, osteoarthritis