Inhibitors of Matrix Metalloproteinases pirimidinonas merged based on ref.pca428-01cfp / BB

摘要

Are Selective inhibitors of MMP - 13 pirimidonas merged the formula or a pharmaceutically acceptable Salt thereof; wherein: W, together with the carbon Atoms to which it is connectedDirradical form an annular 5 miembrosx is o, S, so, SO2, NR5, o CH2 - C -, - S - o; b is either well or NR5; or are taken together to form and B - C = C; R1, R4 and R5 is Hydrogen, alkyl,Alquenilo, aquinilo, (CH2) n - (N - (CH2), cycloalkyl, alcanoilo C1 - C6 or N - (CH2) heteroaryl; R2 and R3 is Hydrogen, alkyl, alquenilo, alquinilo, CN, NO2, nr4r5, (CH2) n - (N - (CH2) cycloalkyl, aryl,O (CH2) n - heteroaryl.R2 can be also Halo; n is an integer from 0 to 5, and yr4 R5, when taken together with nitrogen which are United,Complete a Ring member that contains 3 to 8 Carbon Atoms and optionally contains o, s or n,And is replaced or not replaced; with the exception of R1 and R3 are both selected Hydrogen and alkyl of C1 - C6.