INSULIN SECRETION CONTROLLING AGENTS

摘要

Novel insulin secretion controlling agents are provided. It is found out that IgE-dependent histamine releasing factors (IgE-dependent HRFs) such as tumor-associated protein (TCTP) are controlling factors for insulin secreted from pancreatic β cells. Substances inhibiting the effect of the IgE-dependent HRFs are useful as insulin secretion promoters and preventives and remedies for diabetes, while the IgE-dependent HRFs or substances having the effect are useful as insulin secretion inhibitors.