Combination therapy of angiotensin converting enzyme inhibitor, side-effect reduced amount of aldosterone antagonist and diuretic for treatment of cardiovascular disease

摘要

Combinations of an ACE inhibitor, an aldosterone receptor antagonist and a diuretic, i.e., "triple therapy" combinations, are described for use in treatment of circulatory disorders. of particular interest are triple therapies using captopril or enalapril co-administered with a low-dose of spironolactone and furosemide. This triple therapy would be particularly useful to treat or prevent the progression of congestive heart failure while avoiding or reducing aldosterone-antagonist-induced side effects such as hyperkalemia.