The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through heteroatom linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, O-alkylene-O, -alkylene-O-alkylene-, -aryl-O, O aryl-, (O-alkylene-)m, or (-alkylene-O)m linkage, wherein m is 1-10.
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机译：本发明涉及支化的反应性水溶性聚合物，其包含至少两个聚合物臂，例如聚（乙二醇），其通过杂原子键连接至中心脂族烃核心分子。支链聚合物带有至少一个用于与生物活性剂反应形成生物活性缀合物的官能团。支链聚合物的官能团可以直接连接至脂族烃核或通过中间键连接，例如杂原子，-亚烷基-，O-亚烷基-O，-亚烷基-O-亚烷基-，-芳基-O， O芳基-，（O-亚烷基-） m 或（-亚烷基-O）m键，其中m为1-10。
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