6, 9-disubstituted 2-trans-(4-aminocyclohexyl)amino purines

摘要

The present invention provides novel compounds of the formula (I) ;wherein;R is selected from the group consisting of R2, R2NH, or R3R4NR5- wherein;R2 is selected from the group consisting of C₉-C₁₂ alkyl, ;Z is selected from the group consisting of phenyl, heterocycle, cycloalkyl, and naphthanlene; and M is selected from the group consisting of hydrogen, C₁-C₄ alkyl, and;wherein each C₉-C₁₂ alkyl or Z is optionally substituted with 1 to 3 substituents, which may be the same or different, and which are selected from the group consisting of D, E, ;wherein each D is independently selected from the group consisting of trifluoromethyl, trifluoromethoxy, and C₁-C₄ alkoxy; each E is independently selected from the group consisting of Hal, OH, and C₁-C₈ alkyl; ;R3 and R4 are selected from the group consisting of hydrogen, C₁-C₄ alkyl and (CH₂)_y-phenyl, wherein y is an integer 0-8, with the proviso that R3 and R4 not both be hydrogen;;R5 is C₁-C₈ alkylene; and;R1 is selected from the group consisting of cyclopentyl, cyclopentenyl and isopropyl,;and the pharmaceutically acceptable salts, optical isomers, and hydrates thereof,;with the proviso that when R2 is the group ;wherein n is 1 or greater; R1 is isopropyl or cyclopentyl; R6 is hydrogen, C₁-C₄ alkyl, or (CH₂)_m-phenyl; and Z is phenyl, heterocycle, or cycloalkyl, that Z is substituted with 1 to 3 substituents, which may be the same or different, and which are selected from the group consisting of ;In addition, the present invention provides a method of inhibiting cyclin dependent kinases, particularly cdk-2.;The present invention also provides a method of preventing apoptosis in neuronal cells and a method of inhibiting the development of neoplasms.