Pyrrolopyridazine derivative or a pharmaceutically acceptable salt thereof, pharmaceutical composition, agent containing a pyrrolopyridazine derivative or a pharmaceutically acceptable salt thereof, and use of a pyrrolopyridazine derivative or a pharmaceutically acceptable salt thereof

摘要

"PHYROLOPYRIDAZINE DERIVATIVE OR A SALT OF THIS PHARMACEUTICALLY ACCEPTABLE, PHARMACEUTICAL COMPOSITION, AGENT CONTAINING A PYROLOPYRIDAZINE DERIVATIVE OR A SALT OF THIS PHARMACEUTICALLY ACCEPTABLE DYRACEUALLY DYRACEUTICAL DUE A pyrrolopyridazine compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof. (In formula R1 is C2-6 alkenyl, C2-6 haloalkenyl, optionally substituted C3-7 cycloalkyl or C1-6 alkyl optionally substituted by C3-7 cycloalkyl; R2 is C1-6 alkyl; R3 is hydroxymethyl, C1-6 aliphatic acyloxymethyl (C6-10 aryl) carbonyloxymethyl, (C1-6 alkoxy) carbonyloxymethyl, formyl, carboxy, (C1-6 alkoxy) carbonyl or (C6-10 aryl) oxycarbonyl; R4 is optionally substituted C6-10 aryl and A is imino, oxygen or sulfur). Pyrrolopyridazine Compound is highly effective in inhibiting gastric hydrochloric acid secretion, protecting gastric mucosa and others. This is useful as a medicine, especially a preventative / remedy for ulcerative diseases.