文摘
英文文摘
Abbreviations
Chapter 1 Introduction
1.1 Importance of pyridazine derivatives
1.2 Importance of pyrrolylpyridazine derivatives
1.3 Suzuki cross-coupling reaction in the synthesis of heterocyclic compounds
1.3.1 Introduction to Suzuki cross-coupling reaction
1.3.2 The application of Suzuki cross-coupling in the systhesis of nitrogen heterocycles
Chapter 2 Project design
2.1 Previous synthesis related to pyrrolylpyridazine compounds
2.1.1 Gleave's work
2.1.2 Sauer's work
2.1.3 Jones' work
2.1.4 Clapham's work
2.1.5 Kostyuk's work
2.1.6 Song's work
2.2 Initial plan
Chapter 3 Results and discussion
3.1 Synthesis of pyrrolylpyridazine intermediates
3.2 Suzuki cross-coupling of 3-chloro-6-(2-pyrrolyl)pyridazine with boronic acids
3.3 Conclusion
Chpater 4 Experimental
4.1 General details
4.2 Experimental procedures
References and notes
Appendix
Acknowledgement
Publications