Studies with 2-(acetonylthio)benzothiazole: Novel synthesis of pyridazin-6(1H)-one, pyridazin-6(1H)-imine, and phthalazine derivatives of antimicrobial and antifungal activities

摘要

A novel series of (Z)-1-(arylhydrazono)-1-(benzothiazol-2′-ylthio) propan-2-ones have been prepared and their utility as building blocks in the synthesis of novel derivatives of Pyridazin-6(1H)-ones, pyridazin-6(1H)-imines, and phthalazine incorporating a benzothiazole residue are investigated. All of the title compounds were confirmed by elemental analysis, IR, ~1H NMR, ~(13)C NMR, NOE, and mass spectrometry. The synthesized compounds are screened for their antibacterial as well as antifungal activity. All the tested compounds showed high to moderate activity against the selected microorganisms.