Therapeutic or prophylactic agent for urinary frequency or urinary incontinence or a pharmaceutically acceptable acid addition salt thereof, method for urinary frequency therapy or prophylaxis, urinary urgency or urinary incontinence, use of a morphine derivative having a nitrogen-containing heterocyclic group or a pharmaceutically acceptable acid addition salt thereof, morphine derivative or a pharmaceutically acceptable acid addition salt thereof, pharmaceutical, and pharmaceutical composition

摘要

"THERAPEUTIC OR PROPHYLATIC AGENT FOR URINARY FREQUENCY, OR URINARY INCONTINENCE OR ITS PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT, METHOD FOR URINARY URINARY TREATMENT OF URINARY DYNAMICS, NITROGEN OR ITS PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT, MORPHINE DERIVATIVE OR ITS PHARMACEUTICALLY ACID ADDITION SALT, PHARMACEUTICAL PRODUCT, AND, PHARMACEUTICAL COMPOSITION ". The invention provides a derivative of Formula (I): wherein R1 is methyl, cyclopropylmethyl or the like; R2 and R3 are hydroxy, methoxy, acetoxy or the like; both Y and Z are valence bonds, -C (= O) - or others; X is C 2 -C 5 carbon chain (one of the carbon atoms which may be substituted by oxygen, sulfur or nitrogen) constituting a part of the ring structure, or the like; (R 4 R 4) k is substituted or unsubstituted benzene fused ring, carbonyl group or the like; is hydrogen or others; R 10 and R 11 are bound to represent -O- or the like, and R 6 is hydrogen or the like or a pharmaceutically acceptable acid addition salt thereof. The invention also provides a therapeutic or prophylactic agent for urinary frequency or urinary incontinence, comprising as an effective ingredient the morphine derivative or pharmaceutically acceptable acid addition salt thereof; a method for disease therapy or prophylaxis, and use against disease. The compounds of the invention are useful as a novel therapeutic or prophylactic agent for urinary frequency or urinary incontinence, free of side effects, and useful for the method for disease therapy or prophylaxis and for use against diseases.