Cyclohexylamine derivatives as antagonists of selective n-methyl-d-aspartate subtypes

摘要

"CYCLHEXYLAMINE DERIVATIVES AS ANTAGONISTS OF SELECTIVE N-METHYL-D-ASPARTATE SUBTIPOSES". Derivatives of Formula 1 and pharmaceutically acceptable salts thereof are described, wherein R 1, g, R, V, B, E, Y, G, H, X 1, and d are as defined above in the description. . The compounds of Formulas I and VI are NMDA receptor channel complex antagonists useful for the treatment of cerebral vascular disorders such as, for example, stroke, cerebral ischemia, trauma, hypoglycemia, anxiety, migraine, seizures, Parkinson's disease, hearing loss induced by aminoglycoside antibiotics, psychosis, glaucoma, CMV retinitis, opioid tolerance or withdrawal, chronic pain, or urinary incontinence.