Cyclohexylamine derivatives as subtype selective N-Methyl-D-Aspartate antagonists

摘要

Described are cyclohexylamine derivatives of Formula I ;and pharmaceutically acceptable salts thereof, wherein R₁, g, *, R, V, B, E, Y, G, H, X₁, and d are as defined in the description. The compounds of Formulas I, VI, and VIa are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, stroke, cerebral ischemia, trauma, hypoglycemia, anxiety, migraine headache, convulsions, Parkinson's disease, aminoglycoside antibiotics-induced hearing loss, psychosis, glaucoma, CMV retinitis, opioid tolerance or withdrawal, chronic pain, or urinary incontinence.