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Pharmaceutical formulations of formoterol or ta2005 in stable solution for Pressurised Metered Dose Measurement
Pharmaceutical formulations of formoterol or ta2005 in stable solution for Pressurised Metered Dose Measurement
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机译:用于加压计量剂量的稳定溶液中的福莫特罗或ta2005的药物制剂
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摘要
A composition comprising a drug spray type amino Functional Group wherein has a sensitive oxidation Reactions and / or hydrolysis in a solution of a Liquefied HFA propellant, a pharmaceutically acceptable co Solvent selected from alcohols, where the P H of the solution was adjusted to between 2.5 and 50 by addition of small amounts of a Mineral acid such as hydrochloric acid, nitric acid, fosfu00f3rico.una composition according to clause 2, wherein the PH of the solution was adjusted to 3.0 and 3.5.A composition in accordance with the clauses on 1 - 2, wherein the solution comprises a component with a Low Volatility to low vapour pressure of not more than 0,1kpa, preferably not more than 0,05kpa.A composition according to any preceding clause, wherein the solution comprises at least 0.2% by weight of the component of Low Volatility and no more than 10% by weight. A composition agreement with clauses 1 to 4, wherein the co Solvent is an alcohol, Preferably ethanol.A composition according to any preceding clause, wherein the low volatile component is selected from one or a glycol Ester. A composition according to clause 2, wherein the component of Low Volatility is Isopropyl Myristate.A composition according to any preceding clause, characterized in that the propellant comprises one or more hfas / s selected among the Group comprising HFA 134a or HFA 227.
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