PHOSPHINIC PSEUDO-PEPTIDE DERIVATIVES FOR SELECTIVE INHIBITION OF THE ACTIVE C-TERMINAL SITE OF ANGIOTENSIN CONVERTING ENZYME (I) (ACE)

摘要

The invention relates to the use of phosphine pseudo-peptide derivatives for the preparation of a medicament capable of selectively inhibiting the C-terminal active site of the angiotensin I converting enzyme. These derivatives respond to the following formula: (1) in which: - R1 may be a usual protective group of the amine functions in peptide chemistry, or an amino acid or a peptide protected by this same type of protective groups s, - R2 and R3 correspond to a chain lateral of natural or unnatural amino acid, and- R4 and R5 represent a hydrogen atom or a counterion. Applications: prevention and treatment of cardiovascular pathologies in humans.