Phosphinic pseudo-peptide derivatives for selective inhibition of the active c-terminal site of angiotensin converting enzyme (i) (ace)

摘要

The invention relates to the use of phosphinic pseudopeptide derivatives for production of a medicament for selectively inhibiting the active C-terminal site of angiotensin I converting enzyme. These derivatives are of formula (II): where, RSUB1 /SUBmay be a protecting group for amino functions usually used in peptide chemistry or an amino acid or a peptide protected by the above type of protecting groups, RSUB2 /SUBand RSUB3 /SUBcorrespond to a natural or unnatural amino acid side chain and RSUB4 /SUBand RSUB5 /SUBrepresent a hydrogen atom or a counterion.