DILATED CARDIOMYOPATHY ASSOCIATED GENE-2 (DCMAG-2): A CYTOPLASMATIC INDUCER OF SARCOMERIC REMODELING IN CARDIOMYOCYTES

摘要

The present invention relates to a novel nucleic acid molecule and the protein of DCMAG-2, which is encoded by said molecule and relevant in congestive heart failure. Furthermore, the invention relates to a vector comprising said molecule, antibodies detecting said protein and transgenic non-human mammals overexpressing the corresponding gene product of DCMAG-2. Moreover, the present invention relates to a method of identifying of a compound for treating congestive heart failure which results from aberrant expression or regulation of the gene product of DCMAG-2.