Correlation analysis between serum NT-proBNP level and left ventricular remodeling in patients with dilated cardiomyopathy

摘要

Objective: To study the correlation between serum N-terminal pro-brain natriuretic peptide (NT-proBNP) content and left ventricular remodeling in patients with dilated cardiomyopathy (DCM). Methods: The patients diagnosed with DCM in our hospital between September 2014 and February 2018 were selected as the DCM group, and volunteers receiving physical examination in our hospital during the same period were selected as the control group. Serum NT-proBNP, N-terminal propeptide of procollagen type I (PINP), C-terminal telopeptide of collagen type I (CITP) and matrix metalloproteinase 1 (MMP1) contents as well as echocardiography parameters left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF) and left ventricular mass index (LVMI) were determined. Results: Serum NT-proBNP, PINP, CITP and MMP1 contents as well as LVMI, LVEDV and LVESV levels of DCM group were significantly higher than those of control group while LVEF level was significantly lower than that of control group;serum NT-proBNP content of DCM group was positively correlated with LVMI, LVEDV and LVESV levels as well as serum PINP, CITP and MMP1 contents, and negatively correlated with LVEF level. Conclusion: The increase of serum NT-proBNP in DCM patients is correlated with left ventricular remodeling and NT-proBNP content can be used to evaluate the degree of left ventricular remodeling.