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FAMILY BASED TESTS OF ASSOCIATION USING POOLED DNA AND SNP MARKERS
FAMILY BASED TESTS OF ASSOCIATION USING POOLED DNA AND SNP MARKERS
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机译:使用POOLED DNA和SNP标记进行的家庭关联测试
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摘要
The invention relates to a system and methods for detecting an association in a population of individuals between a genetic locus or loci and a quantitative phenotype. In particular, the present invention relates to family based tests of association using pooled DNA. Disclosed are systems and methods for optimizing pooled tests as an explicit function of measurement error, and for family-based tests that eliminate stratification effects. Also disclosed are modules for identifying functional genetic variants and linked markers using systems and methods that are feasible with cUrrent-day instruments.
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