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BICYCLIC HETEROCYCLES AS RXR LIGANDS

机译:RXR配体的双杂环

摘要

The present invention includes novel retinoid compounds that have selectivity as RXR agonists on one or more isoforms of RXR, currently, RXRα RXRβ, or RXRϜ. The present compounds, an d ph armaceutical compositions incorporating these compounds, therefore, are effective in treating conditions mediated by RXRs. Among other physiological responses, the compounds of the present invention reduce blood glucose and maintain body weight, and, thus, are useful for the treatment of diabetes (NIDDIM) and obesity
机译:本发明包括新颖的类维生素A化合物,其对一种或多种RXR同工型(目前为RXRα,RXRβ或RXR 4)具有选择性作为RXR激动剂。因此,本发明的化合物,掺入这些化合物的dph药物组合物可有效治疗由RXR介导的病症。在其他生理反应中,本发明的化合物降低血糖并维持体重,因此可用于治疗糖尿病(NIDDIM)和肥胖症

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