hipk - kinases and their use for influencing the cell division and cell proliferation

摘要

The invention relates to the use of hipk - kinases, in particular of hipk2 - kinases, as well as of the nucleic acid sequences coding for this, in order to influence the cell division and cell proliferation, in particular the use in a method for the diagnosis or treatment of diseases which are associated with abnormal or excessive cell proliferation are associated, for example, of tumor diseases. Dollars a the invention also relates to the use of hipk - kinases, in particular of hipk2 - kinases, as well as of the nucleic acid sequences coding for this, and specific binding partners for this purpose for identifying and / or the preparation of substances which inhibit the cell division or the zellwachtum, stimulating or in another manner can be influenced. Dollars a the present invention relates in particular to a human hipk2 - kinase and derivatives and fragments thereof, the nucleic acid sequences coding for this as well as antibodies and other specific binding partner for the human hipk2 - kinase and the nucleic acid sequence encoding it.