New N-benzyloxycarbonyl-tyrosine hydrazide derivatives as selective inhibitors of phosphodiesterase-IV, useful for treating e.g. myocardial diseases, asthma, chronic bronchitis and atopic dermatitis

摘要

N-benzyloxycarbonyl-tyrosine hydrazide derivatives (I) and their salts and solvates, as L and or D enantiomers, are new. N-benzyloxycarbonyl-tyrosine hydrazide derivatives of formula (I) and their salts and solvates, as L and or D enantiomers, are new; R1, R2 = hydrogen, hydroxy, OR5, SR5, SOR5, SO2R5, halo or together form methylenedioxy; R3, R4 = R5 or as defined for R1 and R2; R5 = 1-10C alkyl, optionally substituted by 1-5 fluoro and/or chloro, 3-7C cycloalkyl, 5-10C alkylenecycloalkyl or 2-8C alkenyl; halo = fluoro, chloro, bromo or iodo. Independent claims are also included for: (1) a method for preparing (I); and (2) intermediates of formula (III). All definitions are as above.