Modulation of immune responses to foreign antigens expressed by recombinant attenuated bacterial vectors

摘要

The present invention relates to immunogenic compositions comprising a live attenuated derivative of a pathogenic Enterobacteriaceae bacteria. The attenuated derivative of a pathogenic Enterobacteriaceae bacteria comprises a polynucleotide that encodes a foreign antigen. The attenuated derivative of the pathogenic Enterobacteriaceae bacteria has increased expression of Type 1 fimbriae relative to the pathogenic Enterobacteriaceae bacteria from which the attenuated derivative was derived. The present invention also relates to immunogenic compositions that elicit an enhanced Th2 immune response in an individual. The present invention further provides a method of modulating the immune response of an individual comprising administering to said individual the immunogenic compositions of the present invention.