首页> 外国专利> Azabiciclico substituted compounds that act on the receptor alpha7 nicotinic acetylcholine or where there is a deficit in the formation of Sensory Windows and use in preparation of Medicine

Azabiciclico substituted compounds that act on the receptor alpha7 nicotinic acetylcholine or where there is a deficit in the formation of Sensory Windows and use in preparation of Medicine

机译:作用于受体α7烟碱乙酰胆碱或感觉窗口形成不足的阿扎比克西科取代的化合物,并用于制备药物

摘要

1. Azabilis compound (1) substituted in Don M1 is 0 or 1; M2 is 1 or 2; R1 is - H, tar, halogenated tar, substitute tar, cyclopentyl or phenyl; R2 is - H, tar, halogenated tar, substitute tar, cyclopentyl or phenyl, provided that M1 is at least 1r1 and R2 are - H; Or a pharmaceutically acceptable salt, pharmaceutical ingredient, pure corresponding isomer or racemic mixture of the compound. These compounds can be used to develop the pharmaceutical ingredients needed to treat diseases or conditions in mammals,It involves the acetylcholine alfa7 nicotino receptor and treats diseases in mammals, where the formation of sensory window is defective. These compounds can be in the form of pharmaceutically acceptable salts, either pure isomers or racemic mixtures.
机译:1.在Don M1中取代的天青石化合物(1)为0或1; M2为1或2; R1为-H,焦油,卤代焦油,取代焦油,环戊基或苯基; R2为-H,焦油,卤代焦油,取代焦油,环戊基或苯基,条件是M1至少为1r1且R2为-H;或化合物的可药用盐,药物成分,纯的相应异构体或外消旋混合物。这些化合物可用于开发治疗哺乳动物疾病或病症所需的药物成分,涉及乙酰胆碱α7烟碱受体并治疗感觉窗形成有缺陷的哺乳动物疾病。这些化合物可以是药学上可接受的盐的形式,可以是纯异构体或外消旋混合物。

著录项

  • 公开/公告号AR035817A1

    专利类型

  • 公开/公告日2004-07-14

    原文格式PDF

  • 申请/专利权人 PHARMACIA & UPJOHN COMPANY;

    申请/专利号AR2002P101299

  • 发明设计人

    申请日2002-04-09

  • 分类号C07D453/02;C07D487/08;C07D471/08;A61K31/435;A61K31/44;A61K31/445;A61K31/505;A61P25/00;C07D209/00;C07D221/00;C07D223/00;

  • 国家 AR

  • 入库时间 2022-08-21 23:12:25

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