DERIVATIVES OF NUCLEOSIDES AS AN INHIBITORS RNA-DEPENDENT RNA VIRUS POLYMERASE

摘要

In the present invention proposed nucleoside compounds and some of their derivatives, which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and can be used to treat RNA-dependent RNA viral infection. They are particularly useful as inhibitors of the NS5B polymerase of hepatitis C virus (HCV), as inhibitors of HCV replication, and / or for treating hepatitis C infection. The present invention also discloses pharmaceutical compositions containing such nucleoside compounds alone or in combination with other active agents against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods for inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA for viral replication, and / or treating RNA-dependent RNA for viral infection with nucleoside compounds of the present invention. An international search report was published 2002.10.10.