首页> 外文学位 >Part I: Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase. Part II: Synthesis of Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition of HIV Reverse Transcriptase

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Part I: Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase. Part II: Synthesis of Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition of HIV Reverse Transcriptase

机译：第一部分：2'-Fluoro-2'，3'-Dideoxynucleosides的合成作为丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂。第二部分：抑制HIV逆转录酶的膦酸环丁酯和氨基磷酸酯前药的合成

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作者
Neuman, Annette Welty;
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作者单位

Emory University;

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授予单位 Emory University;
学科
学位 Ph.D.
年度 2013
页码 244 p.
总页数 244
原文格式 PDF
正文语种 eng
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专利

1. Synthesis and evaluation of novel phosphoramidate prodrugs of 2'-methyl cytidine as inhibitors of hepatitis c virus NS5B polymerase. [J] . Donghi M, Attenni B, Gardelli C, Bioorganic and Medicinal Chemistry Letters . 2009,第5期

机译：2'-甲基胞苷新磷酸酯前药作为丙型肝炎病毒NS5B聚合酶抑制剂的合成与评价。
2. Synthesis and Anti-HCV Activities of 4 '-Fluoro-2 '-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4 '-Fluoro-2 '-C-methyluridine 5 '-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection [J] . Wang Guangyi, Dyatkina Natalia, Prhavc Marija, Journal of Medicinal Chemistry . 2019,第9期

机译：4'-fluoro-2'-取代的尿苷三磷酸酯和核苷酸前药的合成和抗HCV活性：发现4'-氟-2'-C-甲基嘌呤5' - 磷酸盐的前药（Al-335）用于治疗肝炎 C感染
3. Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives. [J] . Mashino T, Shimotohno K, Ikegami N, Bioorganic and Medicinal Chemistry Letters . 2005,第4期

机译：富勒烯衍生物的人体免疫缺陷病毒逆转录酶抑制和丙型肝炎病毒RNA依赖性RNA聚合酶抑制活性。
4. Design, Synthesis and Study of nucleosidic β-modified phosphonate analogs as potential cN-II inhibitors [C] . Suzanne Peyrottes, Maia Meurillon, Lars P. Jordheim European Symposium on Organic Chemistry . 2009

机译：核苷β-修饰膦酸酯类似物作为潜在的CN-II抑制剂的设计，合成与研究
5. Part I: Synthesis of Cyclobutyl Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1 Reverse Transcriptase Mutant. Part II: Synthesis and Evaluation of Truncated Triptolide Analogs to Suppress Chronic Inflammation [D] . Bluemling, Gregory Richard 2011

机译：第一部分：模拟AZT抑制K65R HIV-1逆转录酶突变体的环丁基核苷类似物的合成。第二部分：截短雷公藤甲素类似物的合成和评估，以抑制慢性炎症
6. Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938 a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine [O] . Angela M. Lam, Christine Espiritu, Eisuke Murakami, 2011

机译：β-d-2-脱氧-2-α-氟-2-β-C-甲基鸟苷的环状磷酸盐前药PSI-352938抑制丙型肝炎病毒复制子RNA的合成
7. Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine▿† [O] . Lam, Angela M., Espiritu, Christine, Murakami, Eisuke, 2011

机译：β-d-2'-脱氧-2'-α-氟-2'-β-C-甲基鸟苷的环状磷酸盐前药PSI-352938抑制丙型肝炎病毒复制子RNA的合成
8. Discovery and Synthesis of GS-5734, a Phosphoramidate Prodrug of a Pyrrolo[2,1 f][triazin-4-amino] Adenine C-Nucleoside for the Treatment of Ebola and Emerging Viruses. [R] . 2017

机译：发现和合成Gs-5734，一种吡咯并[2,1 f] [三嗪-4-氨基]腺嘌呤C-核苷的氨基磷酸酯前药，用于治疗埃博拉病毒和新发病毒。

Part I: Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase. Part II: Synthesis of Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition of HIV Reverse Transcriptase

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