Polymorph V of torasemide a crystalline form of N-(1-methylethyl aminocarbonyl)-4-(3-methyl-phenylamino)-3- pyridinesulfonamide

摘要

Polymorph V of torasemide a crystalline form of N-(1-methylethyl aminocarbonyl)-4-(3-methyl-phenylamino)-3- pyridinesulfonamide, a process for its preparation, its use as a raw material for the preparation of crystalline modifications I and III of torasemide, amorphous torasemide modifications and pharmaceutically acceptable salts of torasemide are disclosed. A pharmaceutical form containing the polymorph V of torasemide as the active ingredient is used as a suitable torasemide form serving as a diuretic or as an agent for preventing heart or heart tissue damages caused by metabolic or ionic abnormalities associated with ischemia, in the treatment of thrombosis, angina pectoris, asthma, hypertension, nephroedema, pulmonary edema, primary and secondary aldosteronism, Bartter's syndrome, tumours, glaucoma, decreasing of intraocular pressure, acute or chronic bronchitis, in the treatment of cerebral edema caused by trauma, ischemia, concussion of the brain, metastases or epileptic attacks and in the treatment of nasal infections caused by allergens.