Barbituric acid analogs as therapeutic agents

摘要

A use of a compound for inhibiting HIF-1 activity in a cell, where the compound has formula (3) where: - Q2 is =O, =S, or =NRN2; - Q4 is =O, =S, or =NRN4; - RC5 may be cis or trans; - Each of RN1, RN2, RN3 and RN4 is a nitrogen substituent, and is independently hydrogen, optionally substituted C1-7alkyl, optionally substituted C3-20 heterocyclyl or optionally substituted C5-20 aryl. The use of the compound described above may extend to inhibiting proliferative diseases (such as cancer) and angiogenesis.