HYPOALLERGENIC DER P1 AND DER P3 PROTEINS FROM DERMATOGRAPHOIDES PTERONYSSINUS

摘要

The present invention provides a treatment for allergy comprising theprovision of a recombinant Der p 1/ProDer p 1/PreProDer p 1 allergenderivative, ProDer p 3 or a recombinant ProDer p 3/Der p 3/ PreProDer p 3allergen derivative with hypoallergenic activity. Pharmaceutical compositionscomprising said mutant allergens which stimulate a Th1-type immune response inallergic or naïve individuals thereby reducing the potential for an allergicresponse upon contact with the wild-type allergen, are also provided.