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HYPOALLERGENIC DER P 1 AND DER P 3 PROTEINS FROM DERMATOGRAPHOIDES PTERONYSSINUS
HYPOALLERGENIC DER P 1 AND DER P 3 PROTEINS FROM DERMATOGRAPHOIDES PTERONYSSINUS
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机译:蕨类植物蕨类植物的低变应原性DER P 1和DER P 3蛋白
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摘要
The present invention provides a treatment for allergy comprising the provision of a recombinant Der p 1/ProDer p 1/PreProDer p 1 allergen derivative, ProDer p 3 or a recombinant ProDer p 3/Der p 3/ PreProDer p 3 allergen derivative with hypoallergenic activity. Pharmaceutical compositions comprising said mutant allergens which stimulate a Th1-type immune response in allergic or naïve individuals thereby reducing the potential for an allergic response upon contact with the wild-type allergen, are also provided.
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机译:本发明提供了一种过敏治疗方法,包括提供具有低变应原活性的重组Der p 1 / ProDer p 1 / PreProDer p 1过敏原衍生物,ProDer p 3或重组ProDer p 3 / Der p 3 / PreProDer p 3过敏原衍生物。 。还提供了包含所述突变型变应原的药物组合物,所述突变型变应原在变态反应的或纯稚的个体中刺激Th1型免疫反应,从而降低了与野生型变应原接触后变应性反应的可能性。
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